Delete items unchecked from a form

I have a list from query that populate checkboxes (checked) in a form.

However, when a user deselects some of the items from, I want them to be deleted from the database for that user.

Here is the ex: this is how the form looks like:

                                         Category

Item                                  80      626

1. HS # 1 (87)                   chk    chk

2. HS #2  (59)                   chk    chk

This is the list of items already n their preferences (db ids)

80|87,  626|87,   80|59,   626|59

Now from a form, if they deselect one of the items (80|87), I want it to be deleted from the database.

Like these, DELETE FROM ITEMS_TBL WHERE ITEM_ID = 80, Category_ID = 87

How can we do it? Can we check ListContains or something else?